Since the hit-and-run murder of his wife five years ago, Rennie Cray has crisscrossed America in his souped-up, stripped-down '68 Plymouth Barracuda, pursuing her killer. The man he seeks in a high-speed, high-stakes game of cat-and-mouse is James Fargo, a merciless, wheelchair-bound pyschopath. Through a series of mechanical innovations, Fargo has turned his rampaging '72 Cadillac Eldorado into a monstrous extension of his own twisted body and mind. Now, their deadly battle of wits and wills is about to move into overdrive. And caught in their headlights is a tormented beauty who unwittingly holds the key to their ultimate showdown.

The paranoid registrant administrator of the Department of Public Safety Erroll Babbage is forced to an early retirement due to his abusive behavior against the sex offenders that he should monitor, and shall spend his last eighteen days training his replacement Allison Lowry. When the seventeen years old Harriet Wells is considered missing in his area of work, Errol is convinced that her disappearance is related to one of his parole sex offenders. However, his superiors do not believe on his investigations and he convinces Allison to follow him in the sick underworld of pornography and perversions trying to find the missing girl.

When a documentary crew traveling through the Amazon jungle, picks up a stranded man, they are unaware of the trouble that will occur. This stranger's hobby is to capture the giant Anaconda snake, and plans to continue targeting it on their boat, by any means necessary.

In the year 3028 A.D., Earth is being attacked by the Drej, which are aliens made of pure energy! The Drej mother-ship destroys Earth with an energy beam just as hundreds of space vehicles manage to escape with the last of mankind aboard! One of the escapees is Sam's young son Cale, who carries with him a ring given to him by his father. Fifteen years later, Cale works on a salvage station, eking out a rough life and hating his father for having disappeared aboard the Titan so long ago. Without a home planet, surviving humans have been reduced to outer space drifters and are constantly bullied and looked down on by other space-faring races. A human captain named Joseph Korso and his pilot Akima seek out Cale and explain that he must help them find the Titan which contains a mechanism that will create a new Earth and therefore unite all of humanity. Meanwhile, the Drej wants to find the Titan so that they can destroy it...

In New York, the ambitious Dr. Jack Byron and his associate Gordon Mitchell present the research of his assistant Sam Rogers to the CEO and board of directors of a corporation to sponsor a scientific expedition to Borneo. The objective is to find a flower, Blood Orchid, that flourishes for a couple of weeks every seven years and could be a fountain of youth, prolonging the expectation of life of human beings. They are succeeded and once in Borneo, they realize that it is the raining season and there is no boat available to navigate on the river. They pay US$ 50,000.00 to convince Captain Bill Johnson and his partner Tran to sail to the location. After an accident in a waterfall, the survivors realize that a pack of anacondas have gathered for mating and their nest is nearby the plantation of Blood Orchid, which made them bigger and bigger.